For the treatment of neurotrophic keratitis (NK)
Take a closer look at oxervate®
When you need to use OXERVATE® you will be supported every step of the way — from access to treatment to the proper preparation and application of OXERVATE.
Important Product Information
Product ID: BP112D47
Product Name: OXERVATE
Brand: Dompé
Expiration date: 01.01.2026
Recall status: NO
Content: cenegermin-bkbj ophthalmic solution 0.002% (20 mcg/mL). Disodium hydrogen phosphate anhydrous (2.87 mg), hydroxypropylmethyl cellulose (1.0 mg), L-methionine (0.01 mg), mannitol (12.22 mg), polyethylene glycol 6000 (10.0 mg), sodium dihydrogen phosphate dihydrate (1.22 mg), trehalose dihydrate (47.03 mg), Water for Injection, USP, and hydrochloric acid and/or sodium hydroxide to adjust pH. OXERVATE does not contain an anti-microbial preservative.
What is OXERVATE?
OXERVATE is the only prescription eye drop FDA‑approved to treat people with neurotrophic keratitis (NK).
How should I use OXERVATE ?
Contact lenses should be removed before applying OXERVATE and may be reinserted 15 minutes after administration.
If a dose is missed, treatment should be continued as normal, at the next scheduled administration.
If more than one topical ophthalmic product is being used, administer the eye drops at least 15 minutes apart to avoid diluting products. Administer OXERVATE 15 minutes prior to using any eye ointment, gel or other viscous eye drops.
Instill one drop of OXERVATE in the affected eye(s), 6 times a day at 2-hour intervals for eight weeks.
What should I avoid while using OXERVATE?
Contact lenses should be removed before applying OXERVATE because the presence of a contact lens (either therapeutic or corrective) could theoretically limit the distribution of cenegermin-bkbj onto the area of the corneal lesion. Lenses may be reinserted 15 minutes after administration.
What are the possible side effects of OXERVATE?
- OXERVATE may cause mild to moderate eye discomfort such as eye pain during your treatment
- Your vision may be blurred for a short time after using OXERVATE. If this happens, wait until your vision clears before you drive or use machines
- In clinical trials, most side effects reported by patients taking OXERVATE were mild and temporary
- The most common side effect was eye pain, reported by about 16% of patients
- Other side effects reported between 1% and 10% of patients treated with OXERVATE were corneal deposits, feeling of having something in the eye, enlarged blood vessels in the white of the eyes, swelling of the eye, sensitivity to light, increase of tears, and headache
Cautionary Advice:
Call your doctor for medical advice about side effects. You may report side effects to Dompé U.S. Inc. at 1-833-366-7387 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
More Information
Stay connected: Register the use of OXERVATE dose on your Digital Dose Recording Table.
How to recycle: COC plastic. Check your local municipality’s regulations on where to dispose of it
